antitrypsin

antitrypsine genotypen

alpha-1-antichymotrypsin: interaction with chymotrypsin-like proteinases

 

Abstract

The interaction of human plasma alpha-1-antichymotrypsin with serine proteinases from different tissues has been investigated. The protein was found to form stable complexes with pancreatic chymotrypsin, leukocyte cathepsin G, and mast cell chymotrypsin. No inhibition of pancreatic trypsin or leukocyte elastase could be demonstrated. With mixtures containing both alpha-1-antichymotrypsin and alpha-1-proteinase inhibitor, it was found that the former preferentially inactivated leukocyte cathepsin G, while the latter showed a strong preference for pancreatic chymotrypsin.

However, leukocyte elastase was specifically inactivated by alpha-1-proteinase inhibitor even in 1:1 mixtures with chymotrypsin. All of these results taken together suggest that one of the primary functions of alpha-1-antichymotrypsin is to inactivate leukocyte cathepsin G, while alpha-1-proteinase inhibitor controls the activity of other serine proteinases, particularly leukocyte elastase.

antitrypsin genotypes
antitrypsin genotypes

 

CYTOMORPHOLOGY OF SOLID-PSEUDOPAPILLARY NEOPLASM:

• highly cellular aspirate
• myxoid or hyalinized vascular stalks lined by neoplastic cells
• delicate granular cytoplasm, indistinct cell borders
• round or oval nuclei
• nuclear grooves
• inconspicuous nucleoli
• foam cells, necrotic debris

FNA yields highly cellular smears composed of a monotonous population of cuboidal cells arranged in loosely cohesive groups, as isolated cells, and, most characteristically, as a single or multiple layer around vascular structures that are often thickened by a myxoid or hyaline material (Fig. 13-7A). The tumor cells have delicate granular cytoplasm with indistinct cell borders. The nuclei are round to oval with finely dispersed chromatin, smooth or grooved nuclear contours, and indistinct nucleoli (Fig. 13-7B). Mitotic figures are usually inconspicuous. The background may contain abundant blood, foam cells, globules of amorphous myxoid material, and necrotic debris.

 

Alpha1-Antitrypsin

A20074 2 ml
EUR 79

Alpha1 Antitrypsin Antibody

7009-100
EUR 338

Alpha1 Antitrypsin Antibody

7009-30T
EUR 146

Alpha 1 Antitrypsin Antibody

abx023941-1mg 1 mg
EUR 648

Human Alpha-1 Antitrypsin

7-06355 100µg Ask for price

Human Alpha-1 Antitrypsin

7-06356 500µg Ask for price

Human Alpha-1 Antitrypsin

7-06357 5mg Ask for price

alpha 1 Antitrypsin Protein

20-abx261417
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

alpha 1 Antitrypsin Protein

20-abx263074
  • EUR 328.00
  • EUR 230.00
  • EUR 1010.00
  • 0.5 mg
  • 100 ug
  • 5 mg

Alpha 1 antitrypsin Antibody

35507-100ul 100ul
EUR 390

alpha-1 antitrypsin fragment

A1051-1 1 mg
EUR 108
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-10 10 mg
EUR 340
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-25 25 mg
EUR 456
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

alpha-1 antitrypsin fragment

A1051-5 5 mg
EUR 224
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

Alpha 1 Antitrypsin Antigen

VAng-Cr3859-3mg 3 mg
EUR 806
Description: Alpha 1 Antitrypsin Antigen, Host/Source: Human Plasma. The purity is ≥95% by SDS-PAGE. It is shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

alpha 1-antitrypsin Antibody

48127-100ul 100ul
EUR 333

alpha 1-antitrypsin Antibody

48127-50ul 50ul
EUR 239

alpha 1 Antitrypsin Antibody

49401-100ul 100ul
EUR 333

alpha 1 Antitrypsin Antibody

49401-50ul 50ul
EUR 239

anti-alpha 1 Antitrypsin

YF-PA13777 100 ug
EUR 403
Description: Rabbit polyclonal to alpha 1 Antitrypsin

Alpha-1-Antitrypsin (SERPINA1) Antibody

20-abx306530
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human α1 Antitrypsin ELISA kit

DEIA-BJ214 96T
EUR 637
Description: This CD α1 Antitrypsin ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human α1-AT. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Alpha-1-Antitrypsin (SERPINA1) Antibody

20-abx115459
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Alpha-1-Antitrypsin (a1AT) Antibody

20-abx101823
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Alpha-1-Antitrypsin (a1AT) Antibody

20-abx101824
  • EUR 300.00
  • EUR 133.00
  • EUR 801.00
  • EUR 425.00
  • EUR 258.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Alpha-1-Antitrypsin (a1AT) Antibody

20-abx101825
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human alpha 1 Antitrypsin Protein

abx060929-1mg 1 mg
EUR 356